Choosing preclinical study models of diabetic retinopathy: key problems for consideration

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Choosing preclinical study models of diabetic retinopathy: key problems for consideration

Diabetic retinopathy (DR) is the most common complication of diabetes mellitus in the eye. Although the clinical treatment for DR has already developed to a relative high level, there are still many urgent problems that need to be investigated in clinical and basic science. Currently, many in vivo animal models and in vitro culture systems have been applied to solve these problems. Many approac...

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Diabetic Retinopathy and Diabetic Eye Problems

Microaneurysms physical weakening of the capillary walls which predisposes them to leakages. Hard exudates precipitates of lipoproteins/other proteins leaking from retinal blood vessels. Haemorrhages rupture of weakened capillaries, appearing as small dots/larger blots or 'flame' haemorrhages that track along nerve-fibre bundles in superficial retinal layers (the haemorrhage arises from larger ...

متن کامل

Diabetic Retinopathy and Diabetic Eye Problems

Microaneurysms physical weakening of the capillary walls which predisposes them to leakages. Hard exudates precipitates of lipoproteins/other proteins leaking from retinal blood vessels. Haemorrhages rupture of weakened capillaries, appearing as small dots/larger blots or 'flame' haemorrhages that track along nerve-fibre bundles in superficial retinal layers (the haemorrhage arises from larger ...

متن کامل

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ژورنال

عنوان ژورنال: Drug Design, Development and Therapy

سال: 2014

ISSN: 1177-8881

DOI: 10.2147/dddt.s72797